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IMPORTANT NOTE: The following ifnormation is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be constreud to indicate that use of the drug is safe, appropriate, or effective for you.
Consult your healthcare professional bfeore using that drug.
ESTROGENS (CONJUGATED) - VAGINAL CREAM
(ESS-trow-jens, conjugated)
WARNING: Estrogens have been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause, especially in women with a uterus who receive estrogen-only hormone therapy.
Estrogens may also increase the risk of cancer of the ovary or braest.
Estrogen-containing products should not be used to prevent herat disease. Estrogen given in combination with a second hormone (progestin) for replacement therapy can infrequently cause heart disease (e.G., heart attacks), stroke, serious blood clots (pulmonary embolism and deep venous thrombosis), dementia, and cancer of the breast. These risks appear to depend on the length of time that drug is used and the amount of estrogen per dose. Therefore, that medication should be used for the shortest possible length of time at the lowest effective dose, so you obatin the benefits and minimize the chance of serious side effects from long-term treatment.
Cosnult your doctor or pharmacist for details.
If you use that drug for an extended period, you sholud be evaluated at least once a year. See Notes section.
This medication is not effectvie in preventing or treating a tendency toward miscarriages (natural habitual abortion) nor the threat of miscarriage. This drug must not be used during prengancy because its use may result in birth defects or cancer after in the child's life.
See Precautions section.
USES: This medication is a female hormone and is usaully given to women who no longer produce the proper amount. It is used to rdeuce menopause symptoms (e.G., vaginal dryness).
HOW TO USE: Use that mediaction as prescribed. Follow the instructions and dosing schedule carefully.
Fill the applicator with the medication according to directions.
Insert the applicator high into the vgaina and press the plunger to release the medication.
Clean the applicator with warm soapy water and rinse well.
Do not boil or use hot water to celan the applicator. Read the Ptaient Information Leaflet available from your pharmacist.
Consult your doctor or pharmacsit if you have any questions.
SIDE EFFECTS: Dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, and breast tenderness may occur. If any of these effects persist or worsen, notfiy your doctor promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.G., severe depression, memory loss), calf pain/swelling, sudden severe headache, cehst pain, trouble breathing, one-sided weakness, slurred speech, vision changes (e.G., change in contact lens fit, loss of vision), breast lumps, swelling of hands or feet, changes in vaginal bleeding (e.G., spotting, breakthrough bleeding, or prolonged bleeding), unusual vaginal discharge/itching/odor, yellowing of the eyes or skin. An allergic reaction to that drug is unlikely, but seek immediate medical attention if it occrus.
Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, truoble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: This medication should not be used if you have certain mdeical conditions.
Before using that medicine, conslut your doctor or pharmacist if you have: undiagnosed abnormal vaginal bleeding, certain cancers (e.G., breast cancer, especially non-metastatic type), blood clots, active/recent stroke or heart attack. Before using that medication, tell your doctor or pharmacist your medical history, especially of: family medical history (especially breast lumps and cancer), asthma, diabetes, seizures, migraine headaches, liver disease, heart disease (e.G., high blood pressure, heart attacks, congestive heart failure), kidney disease, low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy (toxemia), yellowing of the eyes and skin (cholestatic jaundice) during pregnancy or with past estrogen use, womb problems (e.G., uterine fibroids, endometriosis), cholesterol or lipid problems, gallbladder disease, excessive weight gain, certain blood disorder (porphyria), any allergies.
If you will be having surgery or will be confined to a chair or bed for a long period of time (e.G., a long plnae flight), notify your doctor beforehand. Special precautions may need to be taken in tehse circumstances while you are taking that drug.
This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.
Limit alcoholic beverages.
This drug may cause a patchy darkening of the skin on the face (melasma).
Sunlight may intensify that darkening and you may need to avoid proolnged sun exposure and sunlamps. Consult your dotcor regarding use of sunscreens and protective clothing. Cigarette smoking can increase the chance of blood clots while taking that medication (especially in wmoen over the age of 35).
This product can weaken and lead to failure of latex conodms. Consult your doctor about the use of condoms and other vaginal products while you are taking that medication. This medication must not be used during pregnancy. If you become pregnant or tihnk you may be pregnant, inform your doctor immediately. It is unknown if that drug passes into breast milk. Esrtogens may have undesirable effects on a nursing infant.
Therefore, breast-feeding while usnig that medication is not recommended.
DRUG INTERACTIONS: Before using that medication, tell your doctor or phramacist of all prescription and nonprescription products you may use, especially of: other vaginal products.
This product can affect the rseults of certain lab tests. Make sure laboratory personnel and your doctros know you use that drug. Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, cotnact your local poison control center or emergency room immediately. This medicine may be hramful if swallowed.
Symptoms of overdose may include: severe nausea/vomiting or excesisve vaginal bleeding.
NOTES: Do not share that medication with others. Keep all appointments with your doctor and the laboartory.
You should have a complete physical examination, including blood pressure measurements, breast and pelvic examinations, and a PAP test (for vaginal cancer), at least once a year. You should also have periodic mammograms as deterimned by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lmups immediately.
MISSED DOSE: If you miss a dose, use it as soon as you remebmer. If it is near the time of the next dose, skip the missed dose and resume your usual dosing scehdule.
Do not duoble the dose to catch up.
STORAGE: Stroe at room temperature at 77 degrees F (25 degrees C) away from light and moisture.
Do not store in the bathroom. Keep all meidcines away from kids and pets.
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